Acquired Perforating Dermatosis: Clinical and Histopathological Analysis of 95 Patients From One Center

Acquired Perforating Dermatosis: Clinical and Histopathological Analysis of 95 Patients From One Center

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Introduction: Acquired perforating dermatosis (APD) is a disease group characterized by transepidermal elimination of dermal connective tissue materials such as collagen, elastic fibers, and keratin through the epidermis and observed with pruritic skin lesions.Objectives: In this study, we aim to clarify the clinical, histopathological, and dermoscopic characteristics of APD, identify the associated systemic disease, and figure out treatment options.Methods: This study was designed as a single-center retrospective, observational, cross-sectional study.We evaluated all accessible APD cases between January 2004 and June click here 2022 in a tertiary care hospital.

Results: A total of 95 patients with confirmed APD were included in the study.Sixty percent of the patients were women and 40% were men.The median age at diagnosis was 63.1 years (35-85 years).

The most common site of lesions was the lower extremities which were detected in 86.31% of the patients.The concomitant systemic disease was identified in 84.21% of the patients.

The most common systemic disease was type 2 diabetes mellitus (65.26%).Antihistamines and topical old taylor whiskey 1933 price corticosteroids were the most commonly prescribed treatment agents.Conclusions: Transepidermal elimination of dermal connective tissue components is a feature of APD and the disease usually presents with pruritic papules and nodules with central keratotic crust or plug.

The diagnosis of APD requires a clinical examination and histological investigation.APD is usually accompanied by systemic comorbidities.There are several topical and systemic medications available for APD, however, sometimes the therapy might be challenging.